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The story functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels.

PDE5 is a key enzyme tangled in the regulation of cGMP-specific signaling pathways in universal physiological processes such as smooth muscle contraction and relaxation. For this understanding, blockage of the enzyme can alter those pathophysiological conditions associated with a lowering cGMP level off in tissues. For example, discriminatory PDE5 inhibitors, such as sildenafil (Viagra, Pfizer), […]

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